r/IAmA Aug 11 '21 Bravo Grande! 1 Take My Power 1 Silver 11 Gold 2 Helpful 16 Wholesome 3 Hugz 12

I am a cannabis scientist, ask me anything THC, CBD, or any other cannabis related questions, AMA Science

Hi Reddit, Gair Laucius, Chief Science Officer from High Purity Natural Products here, I am here to answer your questions about cannabis, CBD, THC, or any other cannabinoids you want to ask about.

This AMA is closed! Thanks everyone for the great questions, I'm sorry I couldn't answer them all - If you'd like to know more about my company, please visit https://highpuritynaturalproducts.com/about-us/

My experience:

I am an experienced cannabis researcher with expertise in ethanol and super-critical CO2 extraction, gas chromatography mass spectrometry, and high performance liquid chromatography analytics.

I have also conducted research on Cannabis sativa with specific focus on proteins related to cannabinoid biosynthesis pathways. Extensive research experience with DNA and RNA extraction with downstream PCR and qPCR. Highly experienced in terpene and cannabinoid extraction and profiling using HPLC and GCMS.

If it has anything to do with weed, AMA!

Proof: https://twitter.com/HighPurityNP/status/1425475523858341889

Edit: 12:15PM Will be taking a short break for lunch, will return for some more questions shortly. Keep them coming!

Edit2: 1:00PM Wrapping up for now, hope to answer a few more questions later this evening. Thank you to all who asked questions!

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u/ECBright Aug 11 '21

Are the CBD oil products sold in pharmacies 'real' CBD? Do they actually do the things that people claim they do?

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u/wutheringangel Aug 11 '21 Silver Helpful Wholesome

Be careful of Gair's reply here as it's technically correct but also very misleading depending on if you life in the US, as I can't speak to other countries regulations.

CBD sold in pharmacies, convenience stores, kind of everywhere now for the most part are considered "dietary supplements" just like vitamins and the like.

This is very important because even if it's sold in a pharmacy in the US, it's still a dietary supplement. And in the US there are NO REGULATIONS on dietary supplements. They are not inspected by the FDA, you only have the word of the label and who makes it whether what's in it is actually in there or not.

There have been many independent tests done over the years to test whether the label was accurate on different brands of CDB products.

And just like with other OTC dietary supplements, every time they test multiple brands (that I've seen), there are ones that are way off what they claim on label.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818782/

https://www.leafreport.com/education/how-accurate-are-your-cbd-labels-independent-test-results-from-cbd-brands-4250

Do some searching and you'll see this is a real problem with not just CBD products but everything sold as a dietary supplement in the US.

So when Gair says they "certainly contain 'real' CBD", first of all that can't be said for certain unless you have the product tested.

Second, even if it does contain "real" CBD, that doesn't mean it's at the correct dosage or that there are other things in there or missing that could cause side effects.

Stay safe, folks!

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u/thecatwhatcandrive Aug 11 '21

Orrin "sure, fuckin' sell whatever you want and call it a supplement" Hatch sends you a big you're welcome from the great state of Utah

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u/WastedPresident Aug 11 '21

“The government is coming for your vitamin C!”

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u/2SimpleSumtimesNaive Aug 12 '21

The Satanists need to start selling a Tincture of Joseph Smith supplement in Utah until the outrage reaches political crisis levels, I think.

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u/dubnessofp Aug 12 '21

He's highly incentivized to say it works to because he's not just some researcher, he works for a private label manufacturer. As someone who also works in personal care contract manufacturing, I'd use some grains of salt

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u/AllThotsGo2Heaven2 Aug 11 '21 Wholesome

OP answered the question but kind of hedged.

Yes it’s real CBD but generally in person retail shops are gonna be selling a tiny tiny tiny amount. Like 10-20 mg. For like $50.

Read the label and figure out how much is actually in it so you don’t get ripped off.

Terra health essentials: 100mg for $43

Ananda hemp: 300mg for $43

Plant therapy: 1500mg for $40

So if you aren’t paying attention you might be overpaying by up to 15x.

In the immortal words of Wu tang: You gotta read the label

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u/GanonSmokesDope Aug 11 '21

Holy shit that’s criminal. Here in Oregon you can literally buy grams of CBD for like $20

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u/mrme3seeks Aug 11 '21

Man I’m as skeptical as they come if something sounds to good to be true I look up as much info as I can before deciding to try it. After dealing with anxiety most of my life and trying various anti-anxiety medication to try and get rid of the intense butterflies i would get i finally tried CBD gummies just to see what would happen.

I’m honestly blown away. I don’t feel any different at all I carry on as usual I’m just not anxious in the slightest.

Side note I got a medical marijuana card and decided to see if it would help to. Having never used thc in my life it turns me into a complete paranoid mess. I find it super interesting that CBD helps get rid of my anxiety symptoms and then THC amplifies them.

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u/Roupert2 Aug 11 '21

I take CBD for stress associated with personal factors in my life as well as PMDD. CBD doesn't change the way I feel at all except I stop yelling at my kids for no reason on my bad days. It's a really interesting affect. I don't feel different in any way, except that I don't yell at them. That's exactly what I needed, so I'm happy.

It does not help with other symptoms of PMDD but I can deal as long as it isn't affecting my kids.

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u/summerinseattle Aug 11 '21

What brand and dose do you use? I think it might help me but I have no idea where to start.

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u/HPNP Aug 11 '21

CBD products that you find in pharmacies certainly contain 'real' CBD. There is peer reviewed evidence that supports CBD can play a role in pain relief, anti-inflammation, and relieving stress and anxiety.

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u/Daricio Aug 11 '21

If the CBD oil I got from my local pharmacy doesn't seem to work to relieve my anxiety, should I try a different brand? Or just accept that it doesn't work on me?

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u/richie_m_nixon Aug 11 '21

I'm not sure of the legitimacy of this claim, but one of my SoCal dispensary workers once told me that pure CBD won't be as effective as dispensary CBD because there needs to be some small level of THC in CBD to act as an activating agent. Typically in a ratio of 20:1 or 10:1 CBD:THC, something like that.

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u/0rd0abCha0 Aug 11 '21

Yes THC helps CBD to be more active. Also, CBD isolate is not very effective at all. You want a full spectrum hemp or CBD cannabis oil.

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u/carmium Aug 11 '21

Now I know!
I went to a local cannabis shop a while ago when my knee (which had a joint replacement a few years ago) starting screaming at me for doing things like walking. The staffer sold me some capsules with 2.5mg THC and 10mg CBD. Two days, two doses, and I forgot my cane at work and walked home. I am truly amazed at the pain relief, but had wondered why the THC (which isn't enough for any noticeable effect) was included.

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u/aliceinvegasland42 Aug 11 '21 Silver

THC helps for absorption. It more easily passes the blood-brain barrier, allowing for easier absorption of the CBD.

THC also acts as a painkiller, and CBD is primarily an anti-inflammatory. Using them together attacks the pain from two different angles, similarly to using ibuprofen and acetaminophen together: the first calms the inflammation, the second reduces the pain response

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u/Loki_Valravn Aug 11 '21

Thank you so much for this explanation. CBD oil only helped me so much, but smoking helps immensely. I just thought it was because I really like being stoned (I do!)

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u/Flu77ershy Aug 11 '21

What's the difference between THC-A and normal recreational marijuana?

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u/HPNP Aug 11 '21

THC-A is the acid form of THC. THC-A is synthesized by the cannabis plant, the molecule required for users to feel psychoactive effects is delta-9 THC. THC-A is converted to delta-9 THC through decarboxylation which requires heat. (smoking cannabis decarboxylates the THC-A).

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u/Flu77ershy Aug 11 '21

Wait, so if a store sells me THC-A it's functionally the same as a street dealer selling marijuana? (Recreational is not legal in my state (yet))

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u/stumblinghunter Aug 11 '21 edited Aug 12 '21

To put it simpler, THCa is the THC that hasn't been activated for human consumption yet.

To expand, it's the acid form that hasn't decarboxylated yet. Decarbing occurs most frequently when THC is exposed to 255° F. Some animals (dogs, cats) have an enzyme that allows this process after eating it, which is why your pet can get stoned from eating raw flower but you can't. Any edible product you've ever eaten has undergone this process before it's put in your gummies or brownies.

So yes, THCa is just the THC that you haven't smoked yet.

In Colorado, we use the formula THCa * .877 = total THC content. The remaining .133 is regarded as lost THC, or broken down into a number of other cannabinoids (CBD, CDG, CBN, etc).

Edit: Jesus guys. The THC isn't there anymore, I'm explaining it to a newbie. They don't care about its very molar weight

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u/Plantsandanger Aug 11 '21

Huh. So my cat was intentionally getting stoned by chewing my growing plants...

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u/PouchenCustoms Aug 11 '21

No, he is just an ass. 😁

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u/lifeisamitch Aug 11 '21

This is correct. One thing about the formula though... Total THC content = (THCA * 0.877) + THC.

The formula takes into account the amount of THC the end user would use by converting THCA to THC. And the 0.133 difference isn't lost THC or broken down cannabinoids, but rather the loss of CO2 when converting THCA to THC. This is much clearer when you look at the molecular weight of each. Mol wt of THC / Mol wt of THCA = 0.877

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u/stumblinghunter Aug 11 '21

TIL! That all makes sense. Thank you for the correction and info.

But question, that loss could still be considered "lost" THC in a certain sense, right? At least for the purposes of explaining it to someone that doesn't have much knowledge in the matter

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u/BRNZ42 Aug 12 '21

It's not "lost," it's just how chemistry works.

If you bought 1 lb of whole-shell peanuts, you wouldn't expect to get 1 lb of edible peanuts. You've got to take into account the percentage of the total weight that is inedible shell.

In the case of TCHa and THC, THCa has an extra little bit on the end (it's mostly carbon). When you heat it up (decarboxylation) the carbony bit falls off (that's the "carb" in "decarb"). That's like removing the shell to get at the usable peanuts inside. Your conversation factor is literally just the difference in weight between the two forms of the the molecule.

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u/ThatFireGuy0 Aug 11 '21

I've read that those on the autism spectrum have lower circulating cannabinoid levels than neurotypical people. Does this change how they are affected by THC / CBD / etc at all?

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u/2020Bun Aug 12 '21 edited Aug 12 '21

ADD inattentive, weed makes the 10 chattering voices and impulse to play out scenarios in my head, reduce to like 1-2 voices, and a main scenario to play out, and I can focus more on what I’m doing.

Edit: it also diminishes compulsive buying, with the exception of food

Edited for clarity

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u/TheAJGman Aug 12 '21

ADHD here. If I smoke a little then my mind is a whirlwind of creativity. If I smoke a lot it gets whittled down to a few ideas and I can actually concentrate on things, though usually those ideas are "pet the kitty, so soft".

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u/jaypot13 Aug 12 '21

High Functioning ASD and ADHD here. I've found that some of the more energetic strains can make me quite social, much to my delight. I find that some of the low-energy strains make it much more difficult to remember social ques or even want to be social at all. I'm not sure if any of this has anything to do with ASD, though.

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u/[deleted] Aug 12 '21

[removed] — view removed comment

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u/veganstraycat Aug 11 '21

I'm autistic and I get high much faster and much more intensely than neurotypical peers (but that's just myself). I also prefer CBD to THC because I have multiple anxiety disorders.

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u/Void24 Aug 11 '21 Silver

Is there a real genetic difference in today’s sativa and indica strains?

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u/HPNP Aug 11 '21

Today's sativas and indicas have been so heavily crossed between each other that there is virtually no difference. Sativas were traditionally thin leaved and better suited for warmer climates while indica with its broader leaves were found in colder climates native to India and surrounding areas. Today you find "sativas" that were bred with indicas that do great in colder climates with thick leaves and "indicas" with thin leaves. Modern indicas and salivas rely much less on genetics and more on the effect. A strain that gives a more sedated feeling will be labeled an indica and a strain that's more energetic will be labeled a sativa.

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u/THEDrunkPossum Aug 11 '21

A strain that gives a more sedated feeling will be labeled an indica and a strain that's more energetic will be labeled a sativa.

So is this inaccurate then? Since the advent of dispensaries, I've been more educated on terpines, and I've been under the impression that certain terpines are more prevalent in indicators v sativas. Is this simply not true?

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u/WhatAreYouSaying777 Aug 11 '21

Since going solely high grade last year, I can tell for a fact a lot of terms like "couch lock" and "euphoria" specific to one strain are completely BS.

I've found the same exact experiences with both strains. OP is 100% correct in saying that most indica/sativa strains are cross bred, tho barely labeled as such e.g. Hybrids. They just go by the effect e.g. Energetic = Sativa, Sleepy = Indica.

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u/das_vargas Aug 11 '21

I buy by the oz and smoke daily and couldn't tell you the difference ever, I can detect some scents like citrus that are prevalent with sativas, but that's about it.

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u/Checkmate1win Aug 11 '21

If you get a dry herb vape you can taste the difference very clearly at least. It's very enjoyable imo.

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u/dudemo Aug 11 '21

Depends on the vape. I use a vape when I smoke because I don't care to inhale smoke anymore. I own a few vaporizer devices, both portable and for home use. I bought the Pax 3 on recommendations from a few friends that liked it. However, I always found it to be very harsh and dry, even on the lowest setting with some finely ground flower. It got so bad that I quit using it. It almost, but not quite burned the product. So I bought a Firefly 2+. World of difference. I can taste the flower and not the harsh. I barely see any vapor, where with the Pax 3 it was no different than smoking. The battery on the Firefly is much better too.

Ultimately I prefer my home vaporizer. No smell, no smoke, no harsh, and all flavor. I cannot recommend the Volcano Hybrid more. Best product on the market for people like me who prefer the effects of flower over concentrates or edibles but just cannot smoke anymore for various reasons.

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u/Gyrskogul Aug 11 '21

Absolutely a quality product, but the Volcano Hybrid might be a little pricey for someone just stepping into dry herb vaping. To be fair though, everyone's different and will have different preferences. I've gone through ~5 devices and my favorite has been my Underdog log vape. Regardless, dry herb vaping is definitely the way to go if you give a shit about your health but still wanna get high!

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u/Butthole--pleasures Aug 11 '21

I'm using the mighty right now. Very good for taste there's been a few strains that dont give much of a taste. The one I have right now is yummy af though

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u/Sventurbertulu Aug 11 '21

I totally agree about the Volcano. I have had the Digital Volcano for almost 10 years and it works the same as the day I bought it. IMO it gives the best high and you could really taste the flower much better than any other device I've used. Not to mention the amount of money saved by using it. You really cant go wrong with any Storz and Bikel product. The initial investment is high but well worth it.

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u/Prestigious-Mud-1704 Aug 11 '21

Guy that grows dope here (100% not a scientists). My experience with growing and others I know. I have found couch lock specifically, aside from overall strength of the plant, has nearly always been from the colour of the trichomes at harvest. Have had the same plant produce different effects based on harvest, cure and storage.

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u/broski999 Aug 11 '21

is there a way to test the thc content of homemade tincture or edibles?

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u/HPNP Aug 11 '21

Cannabinoid content is calculated via using HPLC (high performance liquid chromatography) you would have to own one or know someone who has one. Best practice would be to use a 3rd party analytical lab.

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u/Richard_Ainous Aug 11 '21

Are 3rd party labs accepting illegal substances? I wanted to get some DMT tested for purity but it didn't seem like a good idea lol

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u/Sharkhottub Aug 11 '21

Are 3rd party labs accepting illegal substances?

3rd Party Cannabis laboratories cannot knowingly accept illegal substances. That being said most 3rd party cannabis labs wont have the ability to test N,N-Dimethyltryptamine unless they have their DEA license and N,N-Dimethyltryptamine as an analyte on their ISO 17025 Scope.

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u/mokes310 Aug 11 '21 Wholesome I'll Drink to That

Mmhmmmm, yes, I understand some of these words...

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u/ethorthedinosaur Aug 11 '21

Are edibles technically healthier since I do not smoke?

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u/HPNP Aug 11 '21 Helpful

Choosing to consume cannabis in a manner which does not require smoking is generally regarded as safer.

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u/BassMasterr Aug 11 '21

How hard are edibles on the liver though ?

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u/[deleted] Aug 11 '21

[deleted]

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u/Tasty_Corn Aug 11 '21

The body doesn't filter THC out of the body through the liver.

It seems that when you smoke it, it goes directly to your bloodstream from your lungs. Edibles are different than smoking and are processed by the liver and converted to a different form of THC, called 11-Hydroxy THC.

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u/philokaii Aug 11 '21 edited Aug 12 '21

Follow up, how come edibles get my mom, little brother, and all my friends SUPER high, but my dad, my older brother, and I can't feel a thing.

Edit.

I have tried ridiculous amounts and types. Sweets, savories, drinks both hot and cold, even food deep fried in infused cooking oil. Homemade and high grade dispensary. People give me nice things promising it'll work because it's strong and I try them, and hours later I'll just feel bad telling them they wasted it on me.

I've eaten them on full bellies, empty bellies, tipsy bellies, sober bellies, you name it. I've eaten them while hiking, while running around with my friends, I've tried showering and eating acidic foods.

I've been hansel and gretel-ing this shit for years, it's just never worked out.

I was hoping that the scientist would explain it to me or have a hack that's backed by research, but instead I'm getting overwhelmed by a lot of anecdotes.

Edit 2

Again, I have gotten the "dank" stuff from the dispensary. I've had more than 1000mg in one sitting. That is 1000. Not 100.

I understand how tolerances and doses work. I understand what mgs are. Taking more really isn't a viable option, because I'd spending more to have one session than on what I could smoke in an entire month.

I've been smoking for over 13 years. I'd like to just eat edibles to save my lungs, but carts are the best I can do. I'm pretty sure I could eat a dispensary's entire stock and walk away feeling nothing.

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u/[deleted] Aug 11 '21

if they're processed by the liver like he said then I imagine natural variation in hepatic enzyme production is the cause

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u/Metalbass5 Aug 11 '21

I'd second this. I have Gilberts syndrome and edibles do dick all to me in doses under 300mg.

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u/hempires Aug 11 '21

You, your bro and your dad might lack or have less of the enzyme required to process it in the liver

https://profofpot.com/cyp3a4-genetics-cannabinoid-metabolism/

I've heard anecdotal reports of trying different 'types' of edible working though (ie couldn't get high off of sweets or cakes but the drinks worked) which could be an avenue to explore?

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u/morriscey Aug 11 '21

Not sure why but some people are very sensitive to edibles - even seasoned smokers. Some people have a natural overall drug resistance as well. Many redheads for example have high pain tolerance and higher resistance to the effects of certain drugs.

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u/PlanetTourist Aug 11 '21

Redhead here, never had full on surgery anesthesia, but been knocked out for 2 dental procedures, woke up in the middle both times.

Ginger resistance is real.

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u/PDXbp Aug 12 '21

Father of 2 redheads, my boy broke his arm recently, the conscious sedation 'worked' in that he had no pain or memory of the initial resetting procedure but he was squirming and fighting and looked like he was writhing in pain. Doc said usually people are effectively asleep but 'some are more active'... then a month later he ended up needing surgery to insert a rod in the ulna and they said he needed a lot of anesthesia and it took him a long time to fully recover. Anyways more anecdotal evidence of the Red Head Resistance.

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u/Lucasaurusawesome Aug 11 '21

What are some negative outcomes for long term smokers?

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u/HPNP Aug 11 '21 Silver

As with inhaling anything into your lungs that is not fresh air, there is the potential for harm to be done. Cannabis contains many tars and resins that act in a similar way to those found in tobacco. Long term cannabinoid exposure does not seem to pose any issues so transitioning from smoking to using ingestibles is a great way to continue enjoying cannabis without potential adverse health outcomes.

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u/crappykillaonariva Aug 11 '21 edited Aug 12 '21

Are there any long-term studies on vaporizing marijuana flower vs smoking it?

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u/bigboypantss Aug 11 '21

I don’t think vaporizing marijuana has been popular for long enough for a long term study. I know a few people that used them 15-20 years ago but i feel like it was very niche until 8-10 years ago.

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u/iwellyess Aug 11 '21

This is an important question

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u/Natdaprat Aug 11 '21

I definitely prefer vaping it.

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u/Ralph-Hinkley Aug 11 '21

I can't even taste the strain anymore in a joint. Just tastes like burnt.

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u/ayeeflo51 Aug 11 '21

IT TASTES LIKE BURNING

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u/TroyAikmanSucks Aug 11 '21

Same here. No hassle, my car or house doesn’t smell like weed and you can smoke it in public pretty inconspicuously. I’ll never smoke any other way now

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u/bono_my_tires Aug 11 '21

It’s certainly less harmful but it’s still not great. Use a vape a few times and it will start getting sticky and covered with resin. You’re still inhaling that stuff into your lungs too. Just not all the extra smoke that comes with combustion.

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u/Adamvs_Maximvs Aug 11 '21

Just want to commend you for this response. Way too many people who are pro-cannabis refuse to ever admit that smoking it (and inhaling anything in general) could to lead to respiratory health issues with enough exposure.

Doesn't mean cannabis itself is bad, just that it isn't necessarily always harmless.

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u/Brock_Samsonite Aug 11 '21

Yeah, I try to be realistic too. I smoke a LOT and am always worried about my lungs. Problem is, all other ways of ingestion just dont have the same effect for me.

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u/Thor_pool Aug 11 '21

Same, its better to live under no illusions though. I knew a guy in his 50s who smoked weed and tobacco like a steam engine, and tried to tell me that weed clears out the tar that builds up from smoking tobacco and undoes all the damage. Yeah, ok dude...

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u/Brock_Samsonite Aug 11 '21

Yeah, I wanna be accurate. I am a disabled vet and basically smoke like a wildfire. If I fuck myself up, I hurt the ones I love. Im already on thin ice.

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u/Cethinn Aug 11 '21

Yeah, this aspect is really annoying. Some people think the studies saying there's no real indication for harm from marijuana mean it's safe to do in any form. Smoking anything is harmful. Some other people think studies showing harm is caused when smoking marijuana mean it's always harmful. Again, smoking anything is harmful.

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u/tilman2015 Aug 11 '21

Long term cannabinoid exposure does not seem to pose any issues

Do we have much research into long term cannabinoid exposure in persons who don't smoke?

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u/giga_booty Aug 11 '21

How about psychological long-term effects?

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u/Jonkinch Aug 11 '21

Every single person I’ve discussed this with says they felt a lot better after quitting. I stopped because I was getting really bad colon spasms more frequently, which is what I used it for. If I used it symptomatically instead of preventative then I would probably be alright.

I would smoke at night only, right before bed for about a year. And I’ve noticed I felt more lazy, like not wanting to do anything, feeling negative more often, just not good I guess all the time. When I stopped I started turning into my chipper self again. Just have a hard time sleeping now...

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u/t-funny Aug 12 '21

Same, I’m trying to stop and it’s harder than I thought. I feel like I’m losing out on so much in life because weed has replaced some of it.

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u/Ill-Bother-6091 Aug 12 '21

That’s what most people say, after years of using they become depressed and overall it just sucks. Either that or paranoia

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u/awhaling Aug 11 '21 Silver

Long term cannabinoid exposure does not seem to pose any issues

As a long time user and being friends with many others, I feel it’s questionable to suggest that it doesn’t seem to pose any issues at all.

Anecdotally, I have seen it cause issues in myself and others, most of which are mild, but issues nonetheless. More concerning is that the heaviest of users, including myself, have suffered from what we believe to be “Cannabinoid Hyperemesis Syndrome”, which is quite a bit more serious. Here is a piece describing what the issue may be: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576702/#!po=1.08696

I think maybe a better way to phrase what you said would be, “there hasn’t been sufficient studies to determine if there are any issues caused by long term cannabinoid exposure”.

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u/black_elk_streaks Aug 11 '21 edited Aug 11 '21

What about CHS (cannabinoid hypermesis syndrome)?

Isn't that a long-term detrimental effect from ingesting cannabinoids to the point where your body's endocannabinoid system is no longer functioning properly?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576702/

Pretty good article that breaks it down for anybody else who's interested in learning more about it.

Edit: spelling error

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u/pollypoppin Aug 11 '21

I have this, it's a god damn nightmare

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u/OhSassafrass Aug 12 '21

When I was in college we called this pipe sickness. The cure was to throw your pipes off a bridge, and take a break for at least a month or two.

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u/Diggydigdug Aug 11 '21

Do you have any concerns about the ever increasing THC concentrations in commercially available weed?

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u/yes420420yes Aug 11 '21

we will see a reversal of that trend soon enough, its insane and follows the typical American more is better philosophy - that ain't so

A lot of people are literally overwhelmed with such product and its experience differs quite a bit from former years

Hopefully we are getting back to the craft beer of weed

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u/Master_Paladin Aug 11 '21

Is Delta 8 safe?

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u/HPNP Aug 11 '21 edited Aug 11 '21 Gold Hugz

As an isolated cannabinoid, Delta-8 THC is lacking in peer reviewed research but has been shown to have a similar effect to delta-9 THC both being psychoactive (Delta-8 less psychoactive than delta-9). Delta-8 THC presents concern for me not because of the cannabinoid but because of the manufacturing process behind making it. Delta-8 is converted from CBD by using harsh chemicals and solvents and if care is not taken to remove these byproducts there is the potential for harm. As a consumer it is extremely difficult, almost impossible to verify how well a delta-8 product was manufactured. My recommendation is to not use delta-8 until more regulation can ensure safety across the board.

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u/Master_Paladin Aug 11 '21

Thanks!

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u/TaxMan_East Aug 11 '21

Delta 8 gummies and vape caused raised eye pressure for me, was very painful but has since gone away.

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u/Creeping_python Aug 11 '21

Yikes that sounds miserable, glad it went away

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u/RooXOXXO Aug 11 '21

Very interesting response. Thank you.

Could the same be said for other d9 concentrates on the black market? Would you say that delta 8 is safer than those?

It seems these products are used mostly in grey states and states where medical/recreational hasn’t taken off yet.

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u/HPNP Aug 11 '21

Sourcing anything that is unregulated such as black market THC is dubious at best. The benefit of purchasing products from legal recreational or medicinal dispensaries is that these programs have regulations to ensure that the products that are sold are tested to ensure safety. Products are tested for Heavy metals, residual solvents, microbials, molds and mycotoxins, and cannabinoids at minimum. The same information cannot be provided for unregulated markets

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u/claytempleton Aug 11 '21

Does this concern include lab tested Delta 8 products in states where cannabis is legal?

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u/Wargician Aug 11 '21

Very curious on this one, its nice to have a legal alternative, but spice was a thing when i was in HS and people died from that. Knowing Delta 8 is safe and legal would be a game changer

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u/sturmblast Aug 11 '21

Spice was also purely synthetic garbage

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u/[deleted] Aug 11 '21

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u/Yeeyeetryptamine Aug 11 '21

What's your favorite strain, Science-dude?

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u/HPNP Aug 11 '21 Hugz

CBD Strain: Stormy Daniels, great name.

THC Strain: Gorilla Glue #4

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u/BongLifts5X5 Aug 11 '21 Gold Helpful Hugz

THC Strain: Gorilla Glue #4

This is the correct answer.

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u/carlbandit Aug 11 '21

I prefer Gelato personally, but I sadly live in a country where it's not legal, so my options are fairly limited and I have no way to verify what I've been told the weed is, is actually what it is.

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u/Trundle-theGr8 Aug 11 '21

Gelato is the best strain on the east coast right now. Best effects of anything I’ve ever smoked.

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u/DriveGenie Aug 11 '21

What method do you usually use? Joints, pipe, vape, oils, etc?

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u/HeisenbergTheory Aug 11 '21

What are the benefits/effects of a 'balanced' CBD:THC strain as opposed to those from high CBD/THC variants?

If I'm trying to cope/deal with social anxiety, should I be reaching for the CBD, THC, or neither?

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u/ComeAbout Aug 11 '21 edited Aug 11 '21 Gold

Combat vet here with PTSD on top of GAD. I’ve replaced all of my “quick acting” anxiety meds with a 4:1 CBD:THC vape pen. Massive upgrade in quality of life.

“CBD keeps you safe” is how I describe it. It stops me from escalating to panic or at least helps me emotionally regulate without side effects.

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u/MayorOfClownTown Aug 11 '21

I'm looking to grow some CBD to mix with my high thc strains. I just get too high and paranoid after a hit or two. I need to think it out with some o'dweeds

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u/phx32259 Aug 11 '21

CBD products seem to block my antidepressants (I think). I see a short term positive effect when I use CBD with several days of feeling super depressed afterwards. How much research is being done with cannabis and how it interacts with prescription drugs?

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u/przemo_li Aug 11 '21

If CBD is legal in your place, please do report your experience with doctor who prescribed those drugs. Your report should be filled as interaction.

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u/Barton-McCombie Aug 11 '21 Helpful Rocket Like

Here's some brand new research on this! CBD, a whole of of phytocannabinoids and their respective acids.

Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characterization https://link.springer.com/article/10.1208%2Fs12248-021-00616-7

TL;DR, interactions may not be too surprising and definitely talk to you doctor about this (if you can).

There's also a host of older research on the topic:

Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions https://onlinelibrary.wiley.com/doi/full/10.1111/epi.16355

Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 https://doi.org/10.2133/dmpk.DMPK-12-RG-129

Comparison in the In Vitro Inhibitory Effects of Major Phytocannabinoids and Polycyclic Aromatic Hydrocarbons Contained in Marijuana Smoke on Cytochrome P450 2C9 Activity https://doi.org/10.2133/dmpk.DMPK-11-RG-107

Cannabidiol, a Major Phytocannabinoid, As a Potent Atypical Inhibitor for CYP2D6 https://doi.org/10.1124/dmd.111.041384

Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes https://doi.org/10.1016/j.bcp.2010.01.028

Interaction between warfarin and cannabis https://doi.org/10.1111/bcpt.13152

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u/Thugnificent3912 Aug 11 '21

Have there been any studies conducted pertaining to marijuana with people with ASD, and if so, what was found?

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u/HPNP Aug 11 '21

There have been a few studies pertaining specifically to the use of Cannabidiol (CBD) in respect to patients with Autism. Daily use of CBD showed improvement across multiple different categories.

The link below is an example of a study done. https://www.frontiersin.org/articles/10.3389/fneur.2019.01145/full

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u/b33t2 Aug 11 '21

For the record I have ADHD and have smoked 2 joints Daily for about a year. for me personally, it allows my mind to slow down and focus on just one thing without thinking about 200 other things happening in my life/environment. While weed is not an ideal solution, for me it has helped, I wish the UK would legalise it so i could get me some edibles regularly.

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u/stuffonyinz Aug 11 '21

So I am just getting diagnosed and didn't understand this until recently, but that is also why I smoke daily. I will smoke so I can function at work and that means having my thoughts slow enough to focus on one thing at a time. It's been incredible finding the ways in which adaptation takes place in our brains to get by!

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u/Cornshot Aug 11 '21

I also have ADHD, and weed has certainly exacerbated a lot of my symptoms. Memory loss, executive dysfunction, anxiety, and depression have all gotten worse with heavy, prolonged use.

I'm glad it's a benefit for you, but I want to emphasize that it's not for everyone, and that the benefits can become negatives with abuse.

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u/tilman2015 Aug 11 '21

Just to add, for anyone reading this, an observational study of 18 people is pretty much useless.

A decent meta-analysis of multiple observational studies would be better but this shouldn't be relied upon.

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u/chocheech Aug 11 '21

Are there conclusive studies on the affects to testosterone levels in both occasional and frequent usage in men?

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u/HPNP Aug 11 '21

There has been some research conducted to examine the relationship between cannabis use and testosterone . Current research shows there is no clinically significant data to suggest a strong relationship.

Here is a recently published meta-analysis which supports this: https://onlinelibrary.wiley.com/doi/pdf/10.1111/andr.12953

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u/UncausedGlobe Aug 11 '21

Delta 8 vs Delta 9. What is really the difference here in composition and effects?

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u/HPNP Aug 11 '21

Delta 8 and Delta 9 THC are separated by the placement of a double bond within the structure of the molecule. Evidence shows that they have very similar effects with both showing psychoactive effects. Delta-9 THC has more psychoactive activity over delta-8 due to the stronger binding affinity.

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u/r00t1 Aug 11 '21 Silver All-Seeing Upvote

Weed causes high anxiety and what seem like panic attacks for me. I’ve tried different strains. What am I doing wrong? It used to be fun.

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u/0rd0abCha0 Aug 11 '21

Try doing something active after you smoke. I find that there are some strains in which I cannot sit and watch a movie or listen to music, as I get anxiety. But I go for a bike ride or start doing something physically - playing piano, cleaning my apartment, and then I feel great.

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u/tweakalicious Aug 11 '21

Weed has gotten stronger. I went through a similar situation where I could smoke indefinitely and then suddenly started getting panic attacks. The panic attacks came right at the onset of dabs...so I was just getting way TOO high.

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u/idkifthisisgonnawork Aug 12 '21

Dabs made me stop smoking all together. My buddy (RIP) had shown me how to smoke dab and let me borrow his rig. I couldnt quite remember how much he said to use so i just grab a big blob (way too much) and put it on there. I took the hit and remember feeling like the back of my brain was melting. I went inside and sat down on the couch and was thinking about shit and looking at a bottle of water sitting on the table. I casually started trying to move the bottle of water with my thoughts, sure that it could be done. I sat there for most of dark side of the moon before i realized that i was trying to move a bottle of water telepathically. I looked up and my wife said, "well?" I said, "i dont think it can be done". She was confused, i was confused. But i remeber not being able to do anything. Like i would feel sick if i started to do too much. And after that i took a break and just never started again.

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u/artlusulpen Aug 11 '21

Exactly. I used to smoke a whole blunt in a sitting 15-20 yrs ago. Now a single hit gets me good for hours.

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u/squid__smash Aug 11 '21 edited Aug 29 '21

this started happening to me all of a sudden, too, after years of daily use with no issues. I've quit now because, while I used to love weed, it simply makes me miserable now.

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u/Gorloftheinsatiable Aug 11 '21

Same…sucks. I always talk myself in to trying it time and time again though. Haha

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u/ikcuts Aug 11 '21

Same! I went a whole year with no issues now I get immediate panic attacks and I've become a hypochondriac

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u/R_eloade_R Aug 11 '21

I have the same dude, to the point if I “force” myself to smoke more (thinking this can’t be) I am thinking that im going insane. Can’t think clear maybe even a psychoses?

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u/alichoturqo Aug 11 '21

I’m the same but I’ve figured it out: small amounts. Take small tokes. Take one small hit and wait an hour before the second one. It’s the only way I smoke it now. Slow and steady. My consumption is down too. I used to go thru almost a gram a day and now it’s like half that. I don’t take huge rips, never get too high. It’s unpleasant and what’s the point of I feel like shit?

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u/SmokeSmokeCough Aug 11 '21

Same here. When I get too high I just started thinking about life and replaying too many old ass memories in my head for no reason and overthinking them lol

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u/alichoturqo Aug 11 '21

Yeah. I get very self critical. I’m too hard on myself.

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u/cosmoceratops Aug 11 '21

Low doses is the truth. Losing your mind is a young person's game. My mind is fragile and I need to be able to see it from where I am.

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u/NoMansUsername Aug 11 '21

I was the same for the last year and a half. Then I found THC infused CBD joints. It changed the way I saw smoking. Try at least a 2:1 CBD to THC strain, then work to higher CBD concentrations if needed. Now I can get high without anxiety and panic attacks.

CBD indirectly boosts serotonin, while high doses of THC lower serotonin. Low serotonin is the primary cause of anxiety. Do your own research of course though.

I thought I’d just have to give up smoking socially, but it turns out I just didn’t understand what I was doing and how the different chemicals involved work.

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u/kom1er Aug 11 '21

That explains why my antidepressants only work when I take CBD. Usually Ssri's don't do much for me and takes weeks to kick in, but when combined with CBD I felt the depression lift within 5 minutes (no exaggeration). I googled it and apparently CBD and Ssri's work synergistically.

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u/rdizzy1223 Aug 11 '21

One odd thing I have found is that vaping weed (whether dry herb vaping or oil) is far more likely to give me those symptoms than smoking it. Also mixing high CBD hemp into the high thc weed always brings down the anxiety (by cutting thc down overall per gram and adding cbd)

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u/[deleted] Aug 11 '21

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u/Chapped_Assets Aug 11 '21 Take My Energy

A vast swath of my patients use, and vast swaths of them remain anxious. People who smoke weed all day because they're anxious/depressed and do nothing else to improve it will remain anxious/depressed. From a psychiatric standpoint, it isn't much different from just taking a couple shots of Jim Beam to cope. Gives me a lot of business, but also causes massive headache for me.

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u/[deleted] Aug 11 '21

If it helps, this thread and your comment have provided direct insight on my own personal issues and I appreciate your experience. It may be time for me to get some proper consultation.

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u/tweekyn Aug 11 '21

Ive smoked since I was 15. Im 30 now and just in the last two years Ive started getting insane panic attacks if I smoke too much. Idk what changed in my body physically but I can handle joints, bong hits, or even more than two hits from a bowl. Now, when I do smoke, I take a tiny hit and blow it out fast. I experience much less panic and anxiety when I do that, but if I hold in the hit for even longer than 2 seconds, Ill be in full on panic mode 10 minutes later. It’s like when you first learn what your limits are with alcohol, baby steps until you figure out whats too much

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u/Foysauce_ Aug 12 '21

Same thing happened to me a year ago. I smoked every single night for years and one day during quarantine last year I ate some edible chocolates with my boyfriend and lost my shit. I felt like I was having a heart attack. I honestly thought I was going to die. It was one of the worst nights of my life.

Didn’t smoke for a few days, but tried hitting the pen one night before bed. After 2 pulls my heart started racing and I couldn’t breathe. Same thing a week later. I haven’t smoked since and I really miss it. I’m so nervous to try again because I never want to feel that way again. My boyfriend still smokes daily and I get jealous :( I think I’m just not in a good head space at the moment.

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u/dukesahn Aug 11 '21

Which method of extraction do you find most suitable on an industrial scale and to preserve terpenes for cartridges and for taste in general? I’m a fan of solventless extraction methods, and outcomes like hash rosin, but have noticed live resin CO2 provides the best tasting cartridge and 4-5 star hash rosin provides the best tasting solventless wax in an affordable range. Is hash rosin able to stay stable inside of a cartridge? Let me know your thoughts and opinions, and which method/s you find most appropriate and economical for the purpose of large scale extract production.

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u/HPNP Aug 11 '21

At scale, sub critical CO2 extraction for terpenes and super critical CO2 extraction for cannabinoids is the best practice. Hash Rosin is not scalable in the same manner as CO2 and it's my personal opinion that CO2 remains top of the food chain for this application.

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u/crappykillaonariva Aug 11 '21 edited Aug 11 '21

I am a regular marijuana user but I limit my use because “hippy hangovers” have hurt my work performance in the past. I have a few questions on (a) why marijuana has certain effects and (b) how I can mitigate these negative effects:

  • Why does marijuana cause dehydration and how does it work? I have noticed that I must increase my fluid consumption significantly to stay hydrated and sometimes I still wake up dehydrated in the mornings. Are there any ways, besides the obvious (i.e. drinking more water) to reduce the dehydrative effects of marijuana? Are there strains that may dehydrate me less than others?
  • I have noticed that if I smoke marijuana too close to the time I fall asleep, my sleep quality suffers (I have a Whoop strap that tracks this data). Typically, if I stop smoking 2 hours prior to falling asleep, I seem to have more restorative and deep sleeps. Is there anything scientific to back this up? Are there other things that I could do to help me sleep better after using marijuana?
  • I have a Storz and Bickel Mighty vaporizer, which is my primary method of consuming marijuana. I typically vaporize at ~185 degrees Cesius. Could I reduce the negative impacts that marijuana has on my body by decreasing or increasing the temperature? Are there other methods of consuming marijuana that would reduce the negative side effects even more (i.e. edibles)? I have noticed anecdotally that edibles often produce very negative “hippy hangovers” but is it possible that I am taking too large of doses (I usually consume ~20 – 40mg of THC)?

Thank you in advance for taking the time to answer questions!

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u/donotdoillegalthings Aug 11 '21

Not OP but marijuana inhibits the REM cycle of sleep, which is where you get the most rest. If you smoke before bed you likely won’t reach the REM stage. This is also why bedtime smokers don’t have dreams.

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u/das_vargas Aug 11 '21 edited Aug 11 '21

That's interesting. I actively dislike dreaming but have always had an issue entering REM sleep even prior to weed because I'm a light sleeper. Weed use pretty much stopped the dreaming which I like, but I don't think I've noticed a correlation with smoking and my sleeping for the past few years.

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u/[deleted] Aug 11 '21 edited Sep 03 '21

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u/[deleted] Aug 11 '21

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u/Metalbass5 Aug 11 '21 edited Aug 11 '21

though this could be put down as withdrawal symptoms.

It is. Been there, done that like 5 times already. By day 7 you'll feel a lot better (99% gone). By day 14 the withdrawals should stop completely. After that it's just a question of your will to avoid it.

Word of warning: I took a 60 day break and got waaaaaay too high when I started again. Your tolerance drops quickly (rises quickly too).

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u/ehickox2012 Aug 11 '21

185° F is that a typo? I have a S&B vape too (a volcano) and I typically use it from 365-380°. 185° F isn’t even enough for the THC to vaporize and have any effect.

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u/crappykillaonariva Aug 11 '21

Ya I meant Celsius. I'll edit this accordingly.

Thanks for pointing that out!!

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u/SinisterG Aug 11 '21

I hope these get answered! I’ve made similar observations around weed hangovers, and sleep quality over the last 3 years.

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u/crappykillaonariva Aug 11 '21

Me too! If there was a way to entirely mitigate the negative effects of the "hippy hangover", it would be amazing.

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u/Mvpeh Aug 11 '21

As a chemical engineer major with extensive chemistry and biology research experience, is it rewarding working with cannabis in a research setting?

Are you hiring?

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u/HPNP Aug 11 '21

It is extremely rewarding working in cannabis research. There is so much to learn about cannabis and individual cannabinoids that we've just scratched the surface.

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u/baibaibhav Aug 11 '21

Can you tell us about cannabis and sleep?

It helps me get to sleep, but I definitely notice a lower quality of sleep. I wonder if it just ain't worth it, should I just struggle to fall asleep?

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u/LettingGo_Part1 Aug 11 '21

I know it's not a very scientific question, but for someone with chronic depression and anxiety, is there a benefit to using one or the other, THC or CBD? Or a benefit for a mix of both?

I've tried CBD droplets with no real luck, and wanted to make an informed decision on where to go next.

Thank you

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u/PM_ur_Rump Aug 11 '21

I am not OP, but a 1:1 blended extract has been the best thing to ever happen to me re: anxiety and depression.

I've used cannabis for decades, but never got any sort of "medical" benefit from it, in fact often the opposite, with it making me sort of over aware of my body and it's functions or any different feeling. Been the type that is not necessarily shy or afraid, more just often in a state of inner tension and constant fight or flight mode, with a history of mild panic attacks.

That's been reduced to near nothing since starting my "regimen." I take a little puff here or there, not much. A gram lasts me about two weeks, and I feel actually more clearheaded and motivated, not stoned.

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u/LettingGo_Part1 Aug 11 '21

Thanks for the insight. I'm honestly at a point that I'm trying to just see if anything works. I'm even considering trying shrooms with all the medical info coming out about psylocibin. I was tired of being on antidepressants, and just want to be better, so my kids and wife grow up and old with a more engaged dad.

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u/Real_Resacky Aug 11 '21

What are the research correlations between THC and Grey matter within the brain?

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u/PopeGuss Aug 11 '21

Do you think we'll ever see nationwide legalization of recreational marijuana?

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u/HPNP Aug 11 '21

Nationwide legalization certainly has plenty of hurdles to overcome. As more individual states independently legalize medicinal and recreational cannabis the pressure for cannabis to become federally legal will tip the scales

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u/djuggler Aug 11 '21

Tennessee wrote it into their constitution that weed will always be illegal.

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u/ImmaculateJones Aug 11 '21 edited Aug 12 '21 Helpful

What are your thoughts on the link between marijuana use and schizophrenia?

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u/[deleted] Aug 11 '21 edited Mar 10 '22 Hugz

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u/juno_huno Aug 11 '21

cannabis hyperemesis syndrome

Is that what this is? I haven’t been a daily smoker that long (2 years only), but lately I’ve been having stomachaches and nausea that only subside a couple hours later.

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u/ABigAmount Aug 11 '21

I believe one of the hallmarks of the syndrome is that the nausea can be resolved by a hot shower- maybe see if that is the case for you.

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u/OriginsOfSymmetry Aug 11 '21

It can help temporarily alleviate it while you're under/in hot water but it won't solve it. Once you're out it's only a matter of time before it's back. At least I've never had hot water actually stop the nausea.

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u/7foot6er Aug 11 '21

what are the functional differences between live resins and distilled thc with terps added. how many more compounds are in a live resin?

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u/Hooligan222 Aug 11 '21

I have been a Daily 1-3 time smoker for over a decade who is now on day 30 of taking a complete break from consuming whilst interviewing for jobs. If I were to have to take a standard employment urinary test, what are the odds it would show up? If it helps I’m 6’1” and 210 pounds, tall thin frame but a bit of a beer belly. :) I read this National Drug Court Institute study saying I’m overwhelmingly unlikely to show more than 50-ng/ML, but am interested to hear your thoughts.

https://www.ndci.org/sites/default/files/ndci/THC_Detection_Window_0.pdf

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u/JEJoll Aug 11 '21

When I toke, I'm frequently very anxious for the first 15 minutes or so, and then settle into a calmer buzz afterwards. Is this normal, and why does it happen?

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u/Nelnar Aug 11 '21

In Norway we are currently having an argument about decriminalizing weed. This discussion is happening all over the media landscape with the police and certain political parties and politicians on one side.

This week the statement that industrial hemp can have the same or similar effect as the weed we use for smoking was brought into the conversation from the police. And there for it most remain illegal. Is this in anyway the truth?

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u/Sikkas Aug 11 '21

Sad that hemp has been grown for centuries all around nordics until criminalisation. And it was used to make ropes and other useful stuff.
I'm guessing the politicians over there are just thinking about the next elections and are very hesitant to do any real progress? That happened here in Finland even though there was a public appeal signed by over 50 000 person. The appeal was even written with different medical uses, home growing suggestions etc etc.. But no. Illegal things are illegal and cannot be made legal because they are illegal.

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u/ryfitz47 Aug 11 '21

Why is there a prevailing belief that indica vs sativa is a key factor in determining the effects of a strain?

I have found that harvest time translates more into effects than indica/sativa/hyrbid. Am I wrong?

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u/Efficient-Floor8719 Aug 11 '21

Grower here. The answer is both. Early harvesting will shift the classification of sativa and indica towards the heady side, late harvesting towards the couch lock side. Plants harvested in their prime will display their typical classifications.

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u/777kiki Aug 11 '21

In the global scientific community what is the consensus on marijuana use during pregnancy? From what I’m told different countries all make different recommendations.

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u/HPNP Aug 11 '21

Cannabis and its relationship to pregnancy is still not very well understood and until that relationship can be better understood the consensus is to not use cannabis while pregnant.

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u/stumblinghunter Aug 11 '21

You will never get a single person to recommend it.

I remember reading a study almost fifteen years ago that smoking while pregnant lead the children to have a different brain schema design (different organizational patterns) vs control, and the majority of the affected kids ended up doing poorer on standardized testing.

It's still a drug, treat it as such

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u/IRENE420 Aug 11 '21

I can’t believe you got downvoted. Please do not use any drugs while pregnant. Even CBD. This is a child’s future we’re talking about, they could live for 80 years with some disability that could be avoided by stopping drug use for 9 months.

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u/Plantsandanger Aug 11 '21

While plenty of people take drugs while pregnant, people specifically asking about it rather than just doing it without the possible considering consequences at all are usually already in a shitty situation - often its that their blood pressure or nausea is so bad that it’s causing problems for the fetus and the pregnant person is prescribed medication to lower the risk of those conditions (BP, nausea) causing harm to the baby (because the risk could cause long term harm or even a miscarriage).

The problem is that some of those drugs have serious side effects, including causing life-threatening birth defects... so it’s a total shit sandwich for the pregnant person who just wants to keep their kid safe and cause the least amount of damage to their baby. But the issue is on one hand their have a fairly well studied doctor-prescribed drug with a shaky history of birth defects and on the other hand you have a not-very-well-studied not-prescribed drug that if known to help those conditions (BP, nausea)... but you fear it might fuck up your kids brain. And your dr is telling you that if you don’t do something to treat your BP or nausea that you WILL harm your baby, and you fear that taking the medicine the dr prescribed might fuck them up, so you start grasping at straws. And there’s weed, looking fairly harmless - it doesn’t cause heart defects or missing limbs, so it seems safer - and you grew up with weed being talked about like it’s as bad as meth so you take advice on the harmfulness of weed with a hefty dash of salt these days, assuming the fear mongering is just that. A lot of people assume the dangers end with smoke (we know smoke gets fetuses via oxygen deprivation) but we have shit knowledge on other means of ingesting. And the studies done on brain development that do exist are in the infancy stage - it often features pregnant people who are ingesting or experiencing multiple negative impacts at once from stress, alcohol, and a plethora of drugs that include marijuana but don’t exclude other drugs... that’s going to result in messy data and conclusions that basically say “lots of teratogens bad but we don’t know exactly which ones did which damage”. I say this as the kid of someone who smoked and ate pot while pregnant with me and who has adhd maybe as a result (it appears it increased the likelihood of me inheriting adhd) so the topic is incredibly personal to me - I went a little nuts researching it and spoke with pharmacologists, psychologists, pharmaceutical drug researchers, marijuana experts, said parinatal nurses and drs, and adhd researchers. The best studies they were able to point me to always had murky conclusions due to the way the studies were forced to be conducted due to ethical concerns, marijuana research prohibitions, and the issue of pregnant people who use marijuana usually experiencing other issues like stress, addictions drug use, or medical issues that may have impacted the baby. The larger the study the less the results could speak to marijuana being the lone culprit, and smaller studies suffered from small sample sizes.

It sucks. We know we have pregnant people using marijuana, I wish we could just study the ones already using it to see how safe or unsafe it is, rather than pushing that research into the dark and having pregnant people just wing it.

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u/stumblinghunter Aug 11 '21

You got downvoted too.

Just don't get high while pregnant. We as a species have known this for quite some time. No, it's not politics. No, it's not cultural. Just don't get high.

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u/777kiki Aug 11 '21

I don’t think it’s about getting high, at least that’s not why i asked. I have an acquaintance who’s kid was born with a birth defect bc of a pharmaceutical prescribed for nausea and her husband wanted her to try pot instead of taking the meds her doctor prescribed. We’ll never know for sure until more research is done, but I personally would not volunteer so I get why there is not a lot of research. I have heard accounts of other countries prescribing medical pot to pregnant women and was curious if anyone knew more.

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u/Trends_ Aug 11 '21

Could you explain what Cannabis Hyperemesis Syndrome is and if there are any known causes other than just having bad luck with long term cannabis use?

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u/fishofmutton Aug 11 '21

Are there any new developments in terms of research on Cannabinoid Hyperemesis Syndrome? As someone that suffered from it and was hospitalized several times before, it would be nice to know a bit more about this and whether researchers are getting any closer to a fix.

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u/flonkerton1 Aug 11 '21

The fix is that if you stop smoking, you'll stop getting sick. It took me a very long time to come to terms with that. I love smoking, but it was killing me. I can smoke small amounts at night and I've been fine, it's when my brain doesn't get a break from it that I've noticed I get sick.

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u/SpaceCadetriment Aug 11 '21

My friend had the same experience, except it took him becoming a father until he finally stopped. He was in agony, profusely vomiting for hours sometimes after smoking. He would call them "abdominal migraines" which apparently some a Dr diagnosed but likely because he wasn't candid about his THC intake. He would always equate the sickness to stress.

Magically, after he stopped smoking they went away, yet his life is much more stressful now that he's a father and another one on the way.

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u/MarkOates Aug 11 '21

I'm only interested in overly-CBD-balanced cannabis flower, but it's becoming increasingly hard to find in Canada.

Why does THC cause such undesirable effects of paranoia and why are they making the calming stuff so much less available for consumers?

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u/Meatpilot Aug 11 '21

I think it is supply and demand that is making it less available.

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u/hedgehogsinhats Aug 11 '21 Hugz Tree Hug

Just how good is Ricky at growing his weed in a trailer?

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u/48x15 Aug 11 '21

it's not rocket appliances

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u/777kiki Aug 11 '21

Water under the fridge

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u/Chrisbee012 Aug 11 '21

Worst case Ontario

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u/[deleted] Aug 11 '21

Where there’s smoke, there’s wires.

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u/snacks4all Aug 11 '21

Friends with the Benedicts

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u/revivemorrison Aug 11 '21

Big enough joint there Rick?

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u/BitterOldPunk Aug 11 '21

We tested his stuff, it passed with flyin’ fuckin’ carpets

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u/randy_lahey934 Aug 11 '21

Two birds stoned at once

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