Yes! It’s the total votes statewide that determines the winner (POTUS and Senator), no matter which areas of the state they come from. Besides that, a showing of more blue votes in red areas makes a bigger statement to powers-that-be, campaign analysts, etc. than blue votes in blue areas. Represent!

And as everyone else is saying, vote blue for every office on the ballot. The state, county, and city levels are just as important as the national level if not more so. Vote in every election no matter what, even if no one you voted for wins, it matters how close the races are so Dems know where to concentrate their efforts.