Well for games it kind of depends on the specific DRM used and how exactly the game utilities it. DRM means digital rights management but there is a wide variety of DRM and ways it’s used.

Some DRM might limit the amount of computers software can be installed on, some might verify the contents to ensure none of the files were changed, some might authenticate with a server before starting up, and some might have kernel level access to read your RAM and log your keystrokes.