Some background on this comic:

Transcript:

This is one of my personal favorites based mostly on one character’s facial expression. The simple “gag” is that Indians and horses are meeting for the first time and handshakes are going all around. But it’s the horse gesturing toward the scenery that I felt “made” this cartoon. I can’t express it, but there’s something captured there that I just like. If I had to draw it over again, the other characters could be drawn a myriad of ways—but I don’t think I could ever replicate that one horse’s expression.

Also, interesting that they edited it to change the width so much.