I wanted to like Guix very much, but eventually found it extremely inflexible. You will miss a lot of packages that are not trivial to create in Scheme yourself. Also a lot of packages have issues that no one wants to fix, or it takes half a year (e.g. being able to use NetworkManager for an eduroam/university wifi connection).

It’s also not possible to just compile a package yourself because the directory structure is totally different.

I don’t think Guix will ever become more flexible, I’ve given up on it