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In my scifi campaign based on Star Control II, all genetic engineering was illegal (one of the primary antagonist groups is a race of blade runner style artificial humans). So of course two of my players teamed up to be an outlaw geneticist and his awakened capuchin monkey. They played it 100% unironically and it resulted in some of the best role-playing it has been my privilege to DM for.
This also happened to me. I dropped out of game art & design school. Now I’m doing art and animation for a game dev company. I took the scenic route, but I got here eventually!