If it is about hormones, why then also not test for growth hormone (GH)? People with more than average GH might have longer legs, giving them an advantage in certain sports. There is also Adrenaline, Cortisone, etc. also giving certain advantages. Maybe we should try to cancel out ALL natural variations, to make the competitions more fair. In the end, we can only allow exact clones from each other to compete to each other. And end up with competitions which equal to throwing a dice, because nobody can be truly be “the best” anymore, which can be defined as “possessing the best set of natural variations that makes this person a born winner”.
All you say might be true for the current design of airplanes. But it is like saying, “this formula 1 race car is really more efficient on the race track than in urban traffic, hence driving cars faster is more efficient.”. I agree flying higher is more efficient. There is however no rule that you need to get to 400kts in order to be able to fly at FL350. It all depends on the design of the airplane. In general, for every form of transportation, road vehicles, boats, airplanes, going faster always means “spending progressively more fuel”. I built my own airplane. And sure enough, flying it at 160kts instead of 140kts costs more fuel, at any altitude. And, not insignificantly, my small propeller airplane has a lower fuel consumption per passenger per mile than the airliners do, despite the latter flying higher and faster… What is the reason of that? There was also the Concorde. It could fly even faster, and higher, but… it used way more fuel. But this also doesn’t mean that flying the Concorde close to its stall speed would be more efficient. There is no way to fly the Concorde at the same efficiency as a 737, at any speed or altitude, because it is designed to fly high and fast, and burn more fuel to make that possible.
So, I’m pretty sure, if we would not optimize the design of airplanes for a certain speed, but for the lowest fuel consumption, you might indeed end up with airplanes that fly slower (and maybe lower) than the designs we have now, and we could have airplanes that use less fuel per passenger per mile.