I can’t speak for base/mid layers, but I wear merino wool socks at work (danish endurance, not 100% but a blend), in steel toe boots, and they last quite a while. Haven’t had any holes or even wearing thin, and I’m notoriously hard on socks and footwear.

I was just watching that episode last week!

Using the arrow keys to go to the entry and pressing shift+delete works for me

The Jeffrey Combs panel is a great one